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RS 102221
CAS No. 187397-18-8
RS 102221 ( RS102221;RS-102221 )
产品货号. M12904 CAS No. 187397-18-8
A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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生物学信息
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产品名称RS 102221
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively.
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产品描述A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively; demonstrates 100-fold selectivity for the 5-HT2C versus 5-HT2A and 5-HT2B receptors; acts as an antagonist in a cell-based microphysiometry functional assay with pA2 of 8.1 and has no detectable intrinsic efficacy; increases food-intake and weight-gain in rats (2 mg/kg, i.p.); reverses the inhibitory effects of MK-212 and DOI on 'monosynaptic and 'intermediate' neurones.
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同义词RS102221;RS-102221
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体5-HT Receptor
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研究领域——
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适应症——
化学信息
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CAS Number187397-18-8
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分子量649.08
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分子式C27H31F3N4O7S.HCl
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纯度>98% (HPLC)
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溶解度——
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SMILESO=S(C1=CC=C(C(F)(F)F)C=C1)(NC2=CC(C(CCCCN(CC3)CCC3(NC(N4)=O)C4=O)=O)=C(OC)C=C2OC)=O.[H]Cl
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化学全称8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bonhaus DW, et al. Neuropharmacology. 1997 Apr-May;36(4-5):621-9.
2. Bonhaus DW, et al. Ann N Y Acad Sci. 1998 Dec 15;861:269.
3. Sévoz-Couche C, et al. Br J Pharmacol. 2000 Dec;131(7):1445-53.
4. McMahon LR, et al. J Neurosci. 2001 Oct 1;21(19):7781-7.
2. Bonhaus DW, et al. Ann N Y Acad Sci. 1998 Dec 15;861:269.
3. Sévoz-Couche C, et al. Br J Pharmacol. 2000 Dec;131(7):1445-53.
4. McMahon LR, et al. J Neurosci. 2001 Oct 1;21(19):7781-7.
产品手册
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